Ireland will be without CJ Stander, Devin Toner, and Garry Ringrose against Scotland.
The trio will miss the Six Nations clash at Murrayfield through injury, with Ireland looking to bounce back from last week's home defeat to England.
Stander picked up facial fractures against England - and could be sidelined for up to four weeks - while Toner has injured his ankle, and Ringrose has damaged his hamstring ahead of Saturday's match.
However, Keith Earls is expected to be fit despite being on the receiving end of some big hits against the English. Andrew Conway is undergoing rehab with Munster over a hamstring injury, but could be fit to face the Scots.
Quinn Roux will likely slot into the second row in place of Toner, whose presence at the line-outs will be a huge loss.
Ringrose's absence could force Joe Schmidt to move Robbie Henshaw back into the centre to partner Bundee Aki, with the introduction of Chris Farrell or Will Adisson providing alternative options.
Sean O'Brien, Jordi Murphy, Rhys Ruddock, and Jack Conan could all be in contention to replace Stander for the next few weeks.
This could also allow Rob Kearney to come back into the team at full back.