Dublin has lost all four of its Euro 2020 matches due to the coronavirus pandemic, with the Ireland capital unable to provide the necessary assurances about minimum capacity crowds.
All three Group E matches have been moved from the Aviva Stadium to St Petersburg in Russia, and Wembley Stadium will now take on an extra last-16 match.
"Preparations for the hosting of the Euro 2020 games in Dublin were at an advanced stage when the pandemic hit and UEFA took the decision on March 17, 2020, to postpone the tournament," Minister for Tourism, Culture, Arts, Gaeltacht, Sport and Media Catherine Martin said.
"Work on the tournament in Dublin continued into 2021 and we were hopeful that we were all set to host a fantastic tournament in Dublin in June.
"However, despite our commitment to hosting the games, the public health situation has meant that we were not able to give UEFA the assurances they required earlier this month in relation to guaranteeing minimum spectator attendance levels at Euro 2020 in Dublin.
"I would like to take this opportunity to wish UEFA and all of the other host cities well with Euro 2020 and look forward to an exciting tournament in the summer."
In Spain, Seville has also replaced Bilbao as a host city.