Ireland have made five changes to the team that lost to England last week to face Scotland on Saturday.
Rob Kearney, Sean O'Brien, Chris Farrell, Quinn Roux, and Jack Conan have all come into the starting lineup for the trip to Murrayfield.
Kearney will slot in at full-back for Robbie Henshaw, who misses out due to a dead leg.
Garry Ringrose's absence means Farrell will come into the centre to partner Bundee Aki, with Roux replacing the injured Devin Toner in the second row.
Conan and O'Brien come in for CJ Stander - who suffered facial fractures against England - and Josh van der Flier respectively.
Leinster star van der Flier drops to the bench, where he is joined by Connacht's Ultan Dillane, the only newcomer since last week's defeat among the replacements.
"Robbie (Henshaw) is unavailable,"Joe Schmidt confirmed. "He got a dead leg and it hasn't recovered sufficiently.
"It was a bit of aggravation after taking a knock against England. The problem is, maybe he could have played, but if you get another bump, it really debilitates you.
"It's exciting to give Chris Farrell the chance against Scotland. He only got one match last year and has come back into form with Munster."
"Once Garry Ringrose was ruled out, it was about keeping continuity as best we can, to be as cohesive as we can be."
Ireland team: R Kearney; K Earls, C Farrell, B Aki, J Stockdale; J Sexton, C Murray; C Healy, R Best (capt), T Furlong; Q Roux, J Ryan; P O'Mahony, S O’Brien, J Conan.
Replacements: S Cronin, D Kilcoyne, A Porter, U Dillane, J Van der Flier, J Cooney, J Carbery, J Larmour.